Beginning with nodal PTCLs, up to 60–100% of angioimmunoblastic T-cell lymphoma (AITL) and up to 40% of PTCL not otherwise specified (PTCL-NOS) demonstrate surface markers of follicular helper T (TFH) cells4–7 and have common genetic features, such asRHOA,TET2,DNMT3A, andIDH8–11. Here, DNMT3A is linked to angioimmunoblastic T-cell lymphoma.