Brentuximab vedotin (BV) is an antibody-drug conjugate comprising an anti-CD30 mAb conjugated to an anti-microtubule agent, monomethyl auristatin E. As CD30 is typically expressed in Hodgkin’s lymphoma and ALCL, most major findings have been achieved in those diseases. This evidence concerns the gene TNFRSF8 and anaplastic large cell lymphoma.