MED12 and leiomyoma: Exome sequencing a small series of leiomyoma tissues identified a high frequency of somatic mutations inMED12 (also known as mediator complex subunit 12) gene22, and a subsequent larger survey of 225 fibroids from 80 patients identifiedMED12 mutations in 70%23, makingMED12 the most frequently altered gene in leiomyomas.MED12 is an X-linked gene that encodes a subunit of the mediator complex that is central to regulation of transcription, and is a crucial element in canonicalWNT signalling, known to interact with β-catenin.