Kim et al. [45] generated the iPSC-like cells from pancreatic ductal adenocarcinoma (PDACs) by introducing the genes encoded OSKM. One cancer iPS-like clone harbored classical PDAC mutations, including kRAS and p16Ink4a heterozygous deletions and decreased SMAD copy number, and retained the chromosomal alterations seen in the parental cells, and differentiated into all three germ layers during in vitro differentiation in the descendants, although the neural lineages were underrepresented. Here, CDKN2A is linked to cancer.