IL6 and systemic sclerosis: After 24-week administration of tocilizumab (162 mg per each subcutaneous weekly injection), skin score estimated by Two-Gene SSc Skin Biomarker was significantly improved in diffuse cutaneous SSc (dcSSc) patients, who had disease duration of <5 years and IL-6-related inflammatory features (the elevation of C-reactive protein, erythrocyte sedimentation rate, or platelet count), compared with the placebo group.