A single amino acid mutation in NLRP3 results in enhanced inflammasome activation, termed cryopyrin-associated periodic syndrome (CAPS), including familial cold autoinflammatory syndrome (FCAS), Muckle–Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID)/chronic infantile neurologic, cutaneous, and arthritis (CINCA) syndrome, which leads to greater IL-1β secretion without DAMPs or PAMPs [22–27]. The gene discussed is IL1B; the disease is CINCA syndrome.