CXCR4 and chronic hepatitis: In contrast, constitutive FGFR1 signaling in LSEC under chronic hepatitis induces the predominance of CXCR4 over CXCR7 by augmenting CXCR4 expression, leading to a shift from pro-regenerative vascular niche to pro-fibrotic phenotype accompanied by the proliferation of activated HSCs.