IL4 and obesity due to melanocortin 4 receptor deficiency: Given the increased incidence of metabolic disorders resulting from the genetic ablation of Th2 or M2 inducers (e.g., Il4, Il13, Il33, Stat6, or Pparg) [33], the decreased whole-body Th2/M2 status resulting from Pla2g5 deficiency may also contribute to the exacerbation of obesity-associated inflammation.