The sPLA2-X-dependent suppression of LXR can also occur in the adipose tissue, where Pla2g10 deficiency facilitates adipogenesis and obesity [48], and in the adrenal glands, where its deficiency promotes corticosteroidogenesis through the activation of steroidogenic acute regulatory protein [49]. The gene discussed is PLA2G10; the disease is obesity due to melanocortin 4 receptor deficiency.