Apart from the crucial role of adipocyte- rather than macrophage-derived sPLA2-V in obesity, the Pla2g5 expression in macrophages is markedly induced by the M2-skewing Th2 cytokines IL-4 and IL-13 and the Pla2g5 ablation decreases the Th2-mediated immune responses [18, 31]. The gene discussed is IL13; the disease is obesity due to melanocortin 4 receptor deficiency.