It is noteworthy that Pla2g1b−/− mice on a Ldlr−/− background are protected from body weight gain and atherosclerosis in response to a hypercaloric diet [43] and that the oral administration of the sPLA2 inhibitor methyl indoxam along with a diabetogenic diet effectively suppresses diet-induced obesity and diabetes in mice likely through the prevention of the intestinal digestion of dietary and biliary PC by sPLA2-IB [44]. The gene discussed is PLA2G10; the disease is obesity due to melanocortin 4 receptor deficiency.