To better characterize the TB lesions and distal regions in the lung tissue biopsies, we investigated the presence of Mtb antigen and the expression pattern of CD68 and CD3 in cryosections from these regions (Figures 7A,B), showing an increased presence of Mtb antigens and CD3-positive cells and a reduction of CD68-positive cells in TB lesions, which is in line with previous observations (Andersson et al., 2007; Rahman et al., 2015). Here, CD68 is linked to tuberculosis.