Even though there is no specific report on vision loss in humans or animals with Cav1.3 mutations, a failure to regulate Cav1.3 is found in a mouse model of Usher syndrome, the most common cause of combined deafness and blindness in humans (Petit, 2001; Kersten et al., 2010; Joiner and Lee, 2015), indicating that Cav1.3 may contribute to retinal function and physiology that requires further investigation. This evidence concerns the gene CACNA1D and blindness (disorder).