The bacterial burden may induce the increase in Treg cells and consequently as the burden released (mycobacterium clearance) Treg cells decreased, which was evidenced from the patients with cavity MDR-TB, showing higher proportion of CD4+CD25 high cells before treatment and CD4+CD25+FoxP3+cells was significantly decreased in peripheral blood at 6-months after surgery45. The gene discussed is CD4; the disease is tuberculosis.