Other targets that were overexpressed in transitional terminators and that have been directly associated with tumor suppression pathways included protein tyrosine phosphatase, non-receptor type 3 (PPTN3)45, fibronectin type III and ankyrin repeat domains 1 (FANK1)46, breast cancer 1, early onset protein (BRCA1)47, protein tyrosine phosphatase, non-receptor type 12 (PTPN12)48, metastasis-associated protein 3 (MTA3)49, and metallophosphoesterase domain containing 2 (MPPED2)50. The gene discussed is BRCA1; the disease is cancer.