These results suggest the involvement of IFNγ in the regulation of the JAK/STAT signaling pathway in EBV (+) GC, consistent with previous evidence showing that IFNγ activates JAK/STAT signaling in hematopoietic cells8 and induces PD-L1 expression through JAK/STAT signaling in lung cancer cells7. This evidence concerns the gene CD274 and lung cancer.