Since Zou et al. 31 for the first time reported a significant association of pTEN rs701848 with laryngo cancer risk in 2006, more evidences have accumulated regarding the relationship between SNP rs701848 and the risk of various cancers, such as lung cancer35, esophageal cancer37–39,41, breast cancer27, prostate cancer15, hepatocellular cancer36, renal cancer7,23, gastric cancer42, and colorectal cancer40. The gene discussed is PTEN; the disease is cancer.