In humans, the phosphatase and tensin homolog deleted on chromosome10 (pTEN)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is frequently activated in a variety of cancers, and play a critical role in many cellular processes including proliferation, differentiation, cell cycle progression, cell motility and tumorigenesis, tumor growth, angiogenesis3–5. Here, PTEN is linked to cancer.