Overall, we observed that carrying mTOR rs2295080 TG or GG genotype and GG/TG genotype showed significant association with decreased cancer risk [TG vs.TT in heterozygote model: OR(95% CI) = 0.82(0.76, 0.89), P < 0.001; GG/TG vs. TT in dominant model: OR(95% CI) = 0.82(0.76, 0.88), P < 0.001; and GG vs.TG/TT in recessive model: OR(95% CI) = 0.67(0.51, 0.88), P = 0.004]. This evidence concerns the gene MTOR and cancer.