A significant association was observed between AKT1 rs2494752 and overall cancer risk, and the heterozygous genotype AG and GG/AG genotype of AKT1 rs2494752 were associated with increased cancer risk (AG vs. AA in heterozygote model: OR(95% CI) = 1.13(1.01, 1.25), P = 0.026; and GG/AG vs. AA in dominant model: OR(95% CI) = 1.13(1.02, 1.25), P = 0.017). The gene discussed is AKT1; the disease is cancer.