Most importantly, the SNP rs2494752 is located at the 5′ UTR of AKT1 gene, a region predicted to be the transcription factor binding region based on the sequence alignments, which may affect the transcription and translation of AKT1. It is plausible that the rs2494752 G allele increased the transcription activity of the promoter in the AKT1 gene, then facilitated the cancer development and progression, which may partially explain the cancer risk associated with this SNP. This evidence concerns the gene AKT1 and cancer.