To date, numerous studies have investigated the association of genetic polymorphisms of pTEN/AKT/mTOR pathway genes including rs2295080, rs2536 of mTOR gene, rs2494750 and rs2494752 in the AKT1 gene, pTEN rs701848 with cancer susceptibility6–9,15–23,28–42, however, the results were inconclusive. Here, PTEN is linked to cancer.