Therefore, the present meta-analysis analyzed the associations of SNPs in the 5′upstream regulatory or promoter region (mTOR rs2295080, AKT1 rs2494752), and 3′UTR region (mTOR rs2536, pTEN rs701848 and AKT1 rs2494750) in the mTOR signaling pathway (AKT, and PTEN) with cancer risk. Here, AKT1 is linked to cancer.