The third network, related to organismal injury and cellular movement, contains 15 upregulated molecules, including GFAP, VIM, S100B, TGFBR2, TGFBR1, TLN1, LAMP2, CSF1 and CSF1R, involved in cytoskeletal arrangement, vacuolisation and activation of glial cells, as previously reported in human AD brains and mouse models20–22 (Network 3, Fig. 3a). The gene discussed is GFAP; the disease is Alzheimer disease.