Among those genes, 10 genes (C4A/C4B, CD74, CTSS, GFAP, NFE2L2, PHYHD1, S100B, TF, TGFBR2 and VIM) were commonly upregulated in the AppNL-G-F/NL-G-F mouse and human AD temporal cortices (Fig. 4). Here, C4B is linked to Alzheimer disease.