Among them, expression of 10 genes (C4A/C4B, CD74, CTSS, GFAP, NFE2L2, PHYHD1, S100B, TF, TGFBR2 and VIM), which are categorised as AD-related by IPA, was increased in the AppNL-G-F/NL-G-F cortex as Aβ amyloidosis progressed with exacerbated neuroinflammation. The gene discussed is TGFBR2; the disease is Alzheimer disease.