The 3xTg-AD-H cortex shared a total of 20 genes (Abhd6, Cyth3, Cckbr, Dusp6, Egr3, Fndc5, Gramd4, Homer1, Kcnf1, Klf10, Mkl1, Nab2, Nptx2, Pcsk1, Qpct, Tet3, Tipin, Trub2, Ttpal and Vegfa) with the human AD hippocampus18, some of which are related to neuronal metabolic and synaptic functions, sugesting that the 3xTg-AD-H cortex mimics hippocampal and to lesser extent cortical profiles in AD patient brains. Here, GRAMD4 is linked to Alzheimer disease.