The 3xTg-AD-H mice that overexpress two mutated human transgenes, Swedish APP (KM670/671NL) and MAPT (P301L) driven by the exogenous neuronal Thy1.2 promoter, with a knock-in mutation of Psen1 (M146V) that promotes formation of Aβ plaques and NFTs, also exhibit behavioural symptoms and Aβ and Tau pathologies before 12 months of age17. The gene discussed is MAPT; the disease is Alzheimer disease.