The third network, related to organismal injury and cellular movement, contains 15 upregulated molecules, including GFAP, VIM, S100B, TGFBR2, TGFBR1, TLN1, LAMP2, CSF1 and CSF1R, involved in cytoskeletal arrangement, vacuolisation and activation of glial cells, as previously reported in human AD brains and mouse models20–22 (Network 3, Fig. 3a). This evidence concerns the gene TGFBR1 and Alzheimer disease.