When we examined the expression levels of 57 genes defined as risk factors for AD by GWAS, together with genes in the immune/microglia module23–30, in our microarray data from human and mouse brains (Table 3, Supplementary Table S10), we found that 13 genes (Abi3, Apoe, Bin2, Cd33, Ctsc, Dock2, Fcer1g, Hck, Inpp5D, Ly86, Plcg2, Trem2, and Tyrobp) were significantly upregulated in the AppNL-G-F/NL-G-F cortex. Here, APOE is linked to Alzheimer disease.