CTSC and Alzheimer disease: Finally, we evaluated the expression levels of 57 genes defined as risk factors for AD by genome-wide association study (GWAS), together with genes in the immune/microglia module (CTSC, DOCK2, FCER1G, HCK, LY86, S100A11, and TYROBP) whose expression is reported to be significantly altered in late-onset AD (LOAD) patients and APPK670N/M671L/PSEN1M146V transgenic mice23–30, in our microarray data from human and mouse brains (Supplementary Table S10).