Specific DMPs were identified for patients with Noonan syndrome, CBL syndrome, somatic PTPN11-, and somatic KRAS mutations (Noonan: 1,313; CBL: 279; PTPN11: 514; KRAS: 122), whereas no specific methylome pattern could be detected for patients with somatic NRAS mutations, NF1 patients, and for quintuple-negative patients (6, 10, and 0 DMPs, respectively). This evidence concerns the gene NRAS and Noonan syndrome.