In addition, the HM group exhibits small but significant expression changes in components of the epigenetic machinery including upregulation of DNMT1 and DNMT3B. However, if the expression changes observed here are sufficient to drive CIMP or if additional secondary regulatory events affect the activity of epigenetic factors needs to be examined in future studies, in order to provide mechanistic insights into how the CIMP in JMML is established. Here, DNMT3B is linked to juvenile myelomonocytic leukemia.