This growing CLL clone yielded additional progeny clone(s) with a CCF of 0.12 at relapse, containing the canonical C481R BTK resistance variant, and two additional previously unreported PLCG2 variants (L848R with a high Polyphen-220 score of 0.993 for a damaging mutation, and an in-frame three base pair deletion in codon E1139del). This evidence concerns the gene PLCG2 and B-cell chronic lymphocytic leukemia.