PROS1 and neoplasm: Another patient (Fig. 5d) with no response to chemotherapy and early progression and death had a pre-treatment single copy deletion of FBXW7, with an additional FBXW7 E111* mutation event detected in the post-treatment tumor (Fig. 5e, f), The acquisition of a bi-allelic loss of FBXW7, a tumor suppressor gene which regulates27 protein degradation of multiple onco-proteins including c-MYC, Notch, Cyclin E, and c-JUN, in the resistant tumor suggests that this event may play a role in resistance.