Similarly, analysis of an Oncomine dataset derived from patient samples reveals that PIK3IP1 expression was significantly lower in human colorectal and lung adenocarcinomas where Ras mutations and activation of Ras signaling pathways are common compared with their corresponding normal tissues or squamous cell lung carcinoma where Ras mutations are uncommon (Supplementary Fig. 8c). Here, PIK3IP1 is linked to lung adenocarcinoma.