Despite the significant fibrosis associated with this disease, there was not a significant upregulation in TGFβ, a very powerful and well-studied cytokine in esophageal remodeling and fibrosis in EoE (Nhu and Aceves, 2017; Cheng et al., 2012; Rieder et al., 2014), in our mice. This evidence concerns the gene TGFB1 and eosinophilic esophagitis.