CD40 and eosinophilic esophagitis: Although several genes were significantly upregulated, defined as a greater than twofold change in expression, in the EoE patients, we found that several genes were increased >100-fold, such as NIK itself (629.16-fold increase), NFKB2/p100 (412.31-fold increase) (Table S1; Fig. 7B), and the noncanonical receptors CD40 (180.17-fold increase) and LTβR (3010.012-fold increase) (Table S1).