The upregulation of several key components of noncanonical NF-κB signaling in human EoE patients including NFKB2 (which encodes the p100 subunit), RELB (a p52 chaperone), NIK itself, and the essential kinase IKKα (encoded by CHUK) in human EoE biopsy samples initially appeared contrary to our findings in our Nik−/− mice. The gene discussed is RELB; the disease is eosinophilic esophagitis.