It is also interesting to note the concurrent dermatitis and esophagitis in the Nik−/− mouse, as atopic dermatitis (AD) can be a co-morbidity of human EoE patients; however, whether the dermatitis of the Nik−/− mouse is primarily an allergic phenomenon as it is in AD is unclear. This evidence concerns the gene MAP3K14 and eosinophilic esophagitis.