Primary ovarian insufficiency (POI), also known as premature ovarian failure (POF), is pathologically characterized by oligomenorrhea or amenorrhea, low levels of gonadal hormones, and high levels of follicle-stimulating hormone (FSH; > 25 mIU/ml) in females before the age of 40 years [1–3]. Here, BRD2 is linked to primary ovarian failure.