CD274 and non-small cell lung carcinoma: Although pembrolizumab is FDA-approved as a single agent in this setting, as well as in combination with carboplatin and pemetrexed for advanced non-squamous NSCLC regardless of PD-L1 status based upon superior progression-free survival and response rates compared with chemotherapy (4 month improvement in progression-free survival compared with chemotherapy), only 45% of patients with single agent, and 55% of patients receiving the triplet combination, experience disease response [37, 38].