These aggregates form different types of tau inclusions: e.g. neurofibrillary tangles and neuropil threads in AD and other tauopathies, argyrophilic grains in argyrophilic grain disease (AGD), oligodendroglial coiled bodies in tauopathies, astrocytic tufts in progressive supranuclear palsy (PSP), astrocytic plaques in corticobasal degeneration (CBD), Pick bodies in Pick disease, etc. (for review see [9, 85]). The gene discussed is MAPT; the disease is Alzheimer disease.