In 4R tauopathies like PSP, AGD and CBD, 4R tau inclusions develop significantly in astrocytes (astrocytic tufts, astrocytic plaques) and in oligodendrocytes (coiled bodies) and the reason for the susceptibility of these glial cells (in addition to neurons) to develop tau aggregates in these tauopathies needs further research. Here, MAPT is linked to tauopathy.