Recent findings showed that monomeric tau (exhibiting unique structure with accessible VQIINK and VQIVYK motifs) derived by sonication from fibrillized tau, seeded aggregation of tau in cells (http://www.alzforum.org/news/conference-coverage/monomeric-seeds-and-oligomeric-clouds-proteopathy-news-aaic). The gene discussed is MAPT; the disease is proteostasis deficiencies.