APP and neurodegenerative disease: The simultaneous occurrence of several types of protein inclusions made of different aggregate-prone proteins characteristic of proteinopathies (alpha-synuclein (α-syn), TAR DNA binding protein-43 (TDP-43), Abeta peptide (Aß)) in tauopathies and other neurodegenerative diseases has been observed regularly [121], suggesting that they might mutually interact.