As shown in Fig. 2c–e, the mRNA expression of IRβ, IRS1, IRS2, and GLUT2 was significantly decreased in the CCl4-injured diabetic rats; while the gene expression levels were effectively increased after ADSC transplantation in the ADSCs treatment group compared with those in the model group, which indicates the alleviators of the insulin resistance in the insulin-affected liver tissues. Here, IRS1 is linked to Insulin resistance.