SOD1 and pancreatic adenocarcinoma: In this work we show that the 5-FU resistant pancreatic adenocarcinoma cells are hypersensitive to PCT (photosensitizer + light) as compared to the 5-FU sensitive control cells, despite a higher de novo expression of SOD1 and SOD2, both potent reactive oxygen (ROS) quenchers, and a higher GSH dependency in the 5-FU resistant cells.