Glioma-derived versican converts microglia into a pro-tumorigenic phenotype characterized by the upregulation of MMP9 and MMP14 (as observed here in response to LPA); in particular, MMP14 promotes activation of GBM-derived MMP2 that favors the invasive potential of malign glioblastoma cells [110]. This evidence concerns the gene VCAN and central nervous system cancer.