WFS1 and deafness: Among these loci, which are designated DFNA (DFN = deafness; A = dominant), DFNA6, DFNA14, and DFNA38 are associated with low-frequency nonsyndromic sensorineural hearing loss (LF-NSHL) and caused by a heterozygous mutation in the Wolfram syndrome 1 (WFS1) gene [1, 2].