Our results demonstrated that miR-200b-3p disrupted c-Myc protein stability through inhibiting AKT2/GSK3β pathway, suggesting that a regulatory loop consisting of the c-Myc/miR-200b-3p/PRDX2 axis and AKT2/GSK3β pathway was involved in regulating CRC progression. The gene discussed is PRDX2; the disease is colorectal carcinoma.