APOE and Alzheimer disease: In a recent example [60], a continuous polygenic hazard score for age-specific AD risk was derived using GWAS SNP (IGAP) data, APOE status, and population-based AD incidence rates in an ADGC cohort, and then tested in independent postmortem (NACC with neuropathology) and premortem cohorts (ADNI with CSF biomarkers).