PNPLA3 and chronic hepatitis C virus infection: Finally, despite these limitations, the data obtained should be added to the extant evidence regarding the roles that the rs738409 polymorphism of the PNPLA3 gene and the rs58542926 polymorphism of the TM6SF2 gene play in hepatic steatosis and advanced fibrosis among individuals with chronic hepatitis C. In addition, this study examined Brazilian patients, who (to the best of our knowledge) have not yet been studied from this perspective.