Unmitigated NF-κB activation can produce proliferation, angiogenesis, mutagenesis,metastasis, and chemo-radio resistance in malignant cells and leave them resistantto apoptosis.11 Patients with advanced cancer exhibit greatly elevated markers of oxidativestress and an unrelenting inflammatory process in part due to NF-κB activation.11 ALA inhibits NF-κB, blunting these deleterious effects and discouraging theunbridled growth of cancer cells. This evidence concerns the gene NFKB1 and cancer.