Previously, we created an HFSTZ APP/PS1 animal model, which displayed diabesity and hepatic steatosis; elevated peripheral Aβ level; enhanced Aβ level, plaque burden, astrocyte activation, vascular inflammation, glucose hypometabolism in the cerebrum, and caused cognitive impairment in APP/PS1 mice [3,4]. This evidence concerns the gene PSEN1 and Cognitive impairment.