Breit et al. indicated that several immune-mediated diseases were associated with an α-1-antitrypsin (A1AT) deficiency including rheumatoid arthritis (RA), anterior uveitis, systemic lupus erythematosus (SLE), and asthma in which A1AT may play roles as an anti-inflammatory and immune regulator [13]. The gene discussed is SERPINA1; the disease is systemic lupus erythematosus.