Breit et al. indicated that several immune-mediated diseases were associated with an α-1-antitrypsin (A1AT) deficiency including rheumatoid arthritis (RA), anterior uveitis, systemic lupus erythematosus (SLE), and asthma in which A1AT may play roles as an anti-inflammatory and immune regulator [13]. This evidence concerns the gene SERPINA1 and rheumatoid arthritis.