NFKB1 and systemic lupus erythematosus: The ability of SINEs to activate NF-κB during infection is consistent with recent observations made in patients with age-related macular degeneration and systemic lupus erythematosus where aberrant expression of Alu RNAs promotes the activation of NF-κB and an inflammasome, as well as cytokine release [63,64,65].