Coincidentally, CHI3L1 and chitin enhances obese inflammation and upregulates the plasma levels of pro-inflammatory glycoprotein YKL-40 according to recent publications [89,92], hence revealing the specific inflammatory regulatory role of CHI3L1 in obese populations and validating the potential relationships between obesity and psychiatric diseases mediated by CHI3L1. Here, CHI3L1 is linked to obesity disorder.