HES1 and central nervous system cancer: More recently, Dantas-Barbosa et al. (2015) showed that pediatric glioma xenografts and the pediatric glioma cell line, SF188, express Notch1, the Notch ligand (DLL1), and several of the Notch pathway’s downstream target genes (HES1, HEY1, MYC and FBXW7), but neither pharmacological nor genetic blockade of Notch1 was capable of reducing pHGG cell growth.