Thereafter, MM cells interact with BMSCs and pre-OBs, through VLA-4/VCAM-1 and CD56/CD56 binding, and, in the latter ones, suppress the activity of the main pro-osteoblastogenic transcription factor, Runt-related transcription factor (Runx)-2, leading to an inhibition of OB differentiation [95]. This evidence concerns the gene VCAM1 and Miyoshi myopathy.