IFNB1 and Zika virus infectious disease: To develop lineage-specific characterizations of ZIKV infection, we compared the in vitro growth rates of two ZIKVAS isolates (SPH and Mex 1-44) and two ZIKVAF isolates (IbH and MR766) in both mammalian and mosquito cells and tested their abilities to overcome the human interferon β-1A (IFN-β) immune response.