SLC7A11 and neoplasm: Likewise, the implication of SLC7A11, a key component of system xċ that imports cystine for the formation of glutathione, highlights the prominent role of glutathione content in APR-246 anti-tumor effect: SLC7A11 appears upregulated after APR-246 exposure [53], or proposed as a predictive biomarker for APR-246 sensitivity [62].