The anti-tumoral effect of PRIMA-1/APR-246 was enhanced when combined to the proteasome inhibitor, bortezomib, in mutant-p53 pancreas cancer cells [32], in wt-p53 Waldenström cells [43] and in myeloma cells, independently of p53 status, with a restoration to sensitivity in bortezomib-resistant cells [54]. The gene discussed is TP53; the disease is plasma cell myeloma.