HIF-1α contributes to induction of stromal cell-derived factor 1 (SDF1α) in the TME, which helps in recruiting vascular modulatory bone marrow-derived cells (BMDCs) to stimulate angiogenesis, vasculogenesis, invasion, and immunosuppression mechanisms in GBM tumors [9]. This evidence concerns the gene CXCL12 and glioblastoma.