TRPV1 and neoplasm: The link between capsaicin receptor and skin tumorigenesis was the subject of an experimental in vivo research which found that topical application of TRPV1-antagonist AMG9810[(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide]promotes tumor development in mice previously treated with DMBA.