TRPV1 and neoplasm: Another study published in 2010 showed that topical application of capsaicin on the skin of TRPV1 wildtype mice and TRPV1 knockout mice, which were previously subjected to the two-stage skin carcinogenesis experiment with DMBA (9,10-Dimethyl-1,2-benzanthracene) and TPA, was associated with significantly more and larger tumors than TPA treatment alone [25].