Brar et al. also showed in a study performed on human melanoma cell lines that reactive oxygen species produced endogenously from nicotinamide adenine dinucleotide phosphate-reduced(NAD(P)H):quinone oxidoreductase activate NF-κB in melanoma cells in an autocrine fashion and that capsaicin significantly reduces proliferation of melanoma cells [66]. This evidence concerns the gene NFKB1 and melanoma.