When we consider the results of the present study, and having science that there is a higher degree of oxidative stress in tissues neoplastic, it is possible that the lower expression of genes OGG1 and MUTYH in tumor tissue, as well as in the variables related to a worse prognosis of the disease, may occur due to the accumulation epigenetic mutations or hypermethylation in these genes by reducing their capacity to repair and favoring the development of a phenotype more aggressive as shown above.11 The gene discussed is OGG1; the disease is neoplasm.