The importance of mutations in the MUTYH gene in colorectal carcinogenesis was highlighted by the Al-Tassan et al. In 2002, where the authors demonstrated for the first time, individuals from the same family who presented biallelic germline mutations in the MUTYH gene and who had recessive forms of familial adenomatous polyposis (FAP), associated with the development of colorectal adenomas presenting progression to CRC in age when compared to the classic forms of FAP.1 This evidence concerns the gene MUTYH and Familial adenomatous polyposis.