Nevertheless, several studies couldshow that changes in selenium status affect, for instance, isoprostane F2αconcentrations, the production of eicosanoid metabolites, and compoundsassociated with heart diseases [50].Associations between GPx-1 activity and cardiac events were found in miceoverexpressing GPx-1; cell damage caused by ischemia in the heart was decreased;and recovery of contractile force was better upon GPx-1 overexpression.Decreased infarct sizes and a significantly decreased release of creatine kinasewere found. This evidence concerns the gene GPX1 and benign neoplasm.