Vladimir R. Muzykantov et al. described the preparation of Protective Antioxidant Carriers for Endothelial Targeting (PACkET) through the controlled precipitation of oleate coated magnetite, SOD, and Pluronic F127 driven by CaCl2, and found SOD-loaded PACkET mitigated cytokine-induced endothelial pro-inflammatory activation and endotoxin-induced lung inflammation [5]. This evidence concerns the gene SOD1 and inflammation.