Complete IL-12p40 and IL-12Rβ1 deficiencies, as well as partial IFN-γR1, IFN-γR2, and STAT1 deficiencies, are generally associated with a later onset disease, milder clinical infections, and a good prognosis (Altare et al. 2001; Casanova and Abel 2002; Casanova et al. 2002; Ottenhoff et al. 2002; Özbek et al. 2005; Reichenbach et al. 2001). The gene discussed is IL12RB1; the disease is infection.