IL12RB1 and tuberculosis: Until 2005, only 4/73 (5.5%) patients with IL-12Rβ1 or IL-12p40 deficiency had been reported to have TB (3/54 patients with complete IL-12Rβ1 deficiency and 1/19 patients with complete IL-12p40 deficiency) (Fieschi and Casanova 2003; Özbek et al. 2005).