However, high IL-6 expression was significantly associated with patients over 40 years (P = 0.033), lower tumour size (P = 0.006), lower tumour grade (P = 0.001), lower Nottingham Prognostic Index (NPI) scores (P < 0.001), positive oestrogen receptor (ER) status (P = 0.046), and positive progesterone receptor (PgR) status (P < 0.001) (Table 2). The gene discussed is PGR; the disease is neoplasm.