Ph-like ALL (also known as BCR-ABL1–like ALL), a recently described subtype of B-ALL, is characterized by a gene-expression profile similar to that of Ph-positive ALL; a variety of genetic alterations that activate tyrosine kinase signaling; the mutation of lymphoid transcription factor genes such as IKZF1 (in 70%–80% of cases); and a poor outcome (5–8). This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.