The first adult model of AML in zebrafish was based on the inv(8)(p11;q13) chromosomal translocation resulting in the oncogenic fusion of MYST3 (also known as MOZ, YBFR2, SAS2, TIP60 family histone acetyltransferase monocytic leukemia 3) and nuclear co-activator 2 [NCOA2, also called transcriptional mediator/intermediary factor 2 (TIF2)]. Here, KAT6A is linked to acute myeloid leukemia.