In this regard, we previously demonstrated that levels of carbonylation of MyHC protein were significantly greater in diaphragm (Marin-Corral et al., 2009; Salazar-Degracia et al., 2016) and limb muscles (Fermoselle et al., 2012; Puig-Vilanova et al., 2014c) of patients with advanced COPD than those detected in the controls. Here, MYH6 is linked to chronic obstructive pulmonary disease.