Levels of creatine kinase, but not carbonic anhydrase-3, were shown to be decreased in diaphragm (Marin-Corral et al., 2009; Ribera et al., 2003) and vastus lateralis (Barreiro et al., 2005; Puig-Vilanova et al., 2014c) of patients with severe COPD and lung cancer cachexia. This evidence concerns the gene CA3 and chronic obstructive pulmonary disease.