RASGRF1 and cancer: Regarding miR-671, besides its role in cancer cell migration [56], it was recently indicated that it regulates apoptotic genes such as caspase 8, p38, Myc-associated factor X (MAX), and Ras protein-specific guanine nucleotide releasing factor 1 (RASGRF1) in neurons of mice [56] and that it suppresses macrophage-mediated inflammation in orbital fat-derived stem cells by upregulating IL-IRA and TNFRII expressions [57, 58] highlighting its potential role in apoptosis and inflammation, both processes involved in OA.