ADIPOQ and Insulin resistance: CREB5 is a primary regulator of adipogenesis, that is also involved in regulating innate immune system, aging-associated inflammation and glucose homeostasis [60, 61] and under obese conditions promotes insulin resistance by activating the transcriptional repressor ATF3 and by downregulating the expression of adiponectin as well as insulin-sensitive glucose transporter 4 (GLUT4) [62].