Recently, it was shown that miR-140 is required for adipogenesis [51]and that decreased levels of miR-140 were found in the plasma of patients with morbid obesity influencing TGFbR1 expression levels [51], suggesting a new role of miR-140 in metabolic processes and obesity, main contributors in OA development. The gene discussed is TGFBR1; the disease is obesity due to melanocortin 4 receptor deficiency.