We found that E2, E2-BSA, or G15 did not directly activate NF-κB p65; E2-BSA enhanced but G15 decreased activation of NF-κB p65 triggered by SLE IgG; E2 did not affect levels of p-NF-κB p65 induced by SLE IgG (Figure S2B in Supplementary Material). This evidence concerns the gene NFKB1 and systemic lupus erythematosus.