To investigate the effect of E2-BSA on expression of intracellular signaling molecules induced by SLE IgG, we analyzed the expression of p-NF-κB p65/NF-κB p65 in Raw264.7 cells treated with SLE IgG in the presence or absence of E2-BSA. This evidence concerns the gene NFKB1 and systemic lupus erythematosus.